Past Journal Clubs

Wednesday, December 16, 12 pm (noon) EST 

Title: Reward enhances pain discrimination in humans


Presented by: Dr. Susanne Becker, Research Group Leader, Integrative Spinal Research, Department of Chiropratic Research, University of Zurich, Switzerland

 

Abstract: The notion that reward inhibits pain is a well-supported observation in both humans and animals, allowing suppression of pain reflexes to acquired rewarding stimuli. However, a blanket inhibition of pain by reward would also impair pain discrimination. In contrast, early counterconditioning experiments implied that reward might actually spare pain discrimination. To test this hypothesis, we investigated whether discriminative performance was enhanced or inhibited by reward. We found in adult human volunteers (N = 25) that pain-based discriminative ability is actually enhanced by reward, especially when reward is directly contingent on discriminative performance. Drift-diffusion modeling shows that this relates to an augmentation of the underlying sensory signal strength and is not merely an effect of decision bias. This enhancement of sensory-discriminative pain-information processing suggests that whereas reward can promote reward-acquiring behavior by inhibition of pain in some circumstances, it can also facilitate important discriminative information of the sensory input when necessary.

Relevant Paper: CLICK HERE

Monday, November 23, 8 am EST 

Title: Striatal hypofunction as a neural correlate of mood alterations in chronic pain patients


Presented by: Ellie Minhae Kim, Senior Clinical Research Coordinator, Pain and Neuroinflammation Imaging Lab (Dr. Marco Loggia), A.A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Boston, MA, USA

 

Abstract: Chronic pain and mood disorders share common neuroanatomical substrates involving disruption of the reward system. Although increase in negative affect (NA) and decrease in positive affect (PA) are well-known factors complicating the clinical presentation of chronic pain patients, our understanding of the mechanisms underlying the interaction between pain and PA/NA remains limited. Here, we used a validated task probing behavioral and neural responses to monetary rewards and losses in conjunction with functional magnetic reso- nance imaging (fMRI) to test the hypothesis that dysfunction of the striatum, a key mesolimbic structure involved in the encoding of motivational salience, relates to mood alterations comorbid with chronic pain. Twenty-eight chronic musculoskeletal pain patients (chronic low back pain, n1⁄415; fibromyalgia, n1⁄413) and 18 healthy controls underwent fMRI while performing the Monetary Incentive Delay (MID) task. Behavioral and neural responses were compared across groups and correlated against measures of depression (Beck Depression Inventory) and hedonic capacity (Snaith-Hamilton Pleasure Scale). Compared to controls, patients demonstrated higher anhedonia and depression scores, and a dampening of striatal activation and incentive-related behavioral facilitation (reduction in reaction times) during reward and loss trials of the MID task (ps < 0.05). In all participants, lower activation of the right striatum during reward trials was correlated with lower incentive-related behavioral facilitation and higher anhedonia scores (ps < 0.05). Finally, among patients, lower bilateral striatal activation during loss trials was correlated with higher depression scores (ps < 0.05). In chronic pain, PA reduction and NA increase are accompanied by striatal hypofunction as measured by the MID task.

Relevant Paper: https://scholar.harvard.edu/files/loggia/files/striatal-hypofunction-as-a-neural-correlate-of-mood-alterations_2020_neuroim.pdf

Thursday, October 22, 3pm EST 

Title: The Distributed Nociceptive System: A Framework for Understanding Pain


Presented by: Dr. Robert C. Coghill, Director, Center for Understanding Pediatric Pain (CUPP), Professor of Pediatrics Behavioral Medicine and Clinical Psychology, Cincinnati Children’s Hospital Medical Center

 

Abstract: Chronic pain remains challenging to both diagnose and treat. These challenges, in part, arise from limited systems-level understanding of the basic mechanisms that process nociceptive information and ultimately instantiate a subjectively available experience of pain. Here, I provide a framework, the distributed nociceptive system, for understanding nociceptive mechanisms at a systems level by integrat- ing the concepts of neural population coding with distributed processing. Within this framework, wide-spread engagement of populations of neurons produces representations of nociceptive information that are highly resilient to disruption. The distributed nociceptive system provides a foundation for understanding complex spatial aspects of chronic pain and provides an impetus for nonpharmacological cognitive and physical therapies that can effectively target the highly distributed system that gives rise to an experience of pain.

Relevant Paper: https://doi.org/10.1016/j.tins.2020.07.004

Wednesday, September 23, 3pm EST 

Title: Using fMRI hyperscanning to investigate the patient-clinician relationship in chronic pain: The role of therapeutic alliance, behavioral mirroring, and brain-to-brain concordance in therapeutic pain relief


Presented by: Dr. Dan-Mikael Ellingsen, Postdoctoral research fellow (Napadow Lab), Harvard Medical School and Martinos Center for Biomedical imaging, Boston, USA.

 

Abstract: The patient-clinician interaction can powerfully shape treatment outcomes such as pain, but is often considered an intangible “art-of-medicine”, and has largely eluded scientific inquiry. Although brain correlates of social processes such as em- pathy and theory-of-mind have been studied using single-subject designs, the spe- cific behavioral and neural mechanisms underpinning the patient-clinician interac- tion are unknown. Using a two-person interactive design, we simultaneously rec- orded functional MRI (i.e. hyperscanning) in patient-clinician dyads, who interacted via live video while clinicians treated evoked pain in chronic pain patients. Our re- sults show that patient analgesia is mediated by patient-clinician nonverbal behav- ioral mirroring and brain-to-brain concordance in circuitry implicated in theory-of- mind and social mirroring. Dyad-based analyses showed extensive dynamic cou- pling of these brain nodes with the partners’ brain activity, yet only in dyads where clinical rapport had been established prior to the interaction. These findings point to a putatively key brain-behavioral mechanism for therapeutic alliance and psycho- social analgesia.

Relevant Paper: Ellingsen et al. Dynamic brain-to-brain concordance and behavioral mirroring as a mechanism of the patient-clinician interaction. bioRxiv 2020.08.05.237511

https://www.biorxiv.org/content/10.1101/2020.08.05.237511v1

Thursday, August 6, 3pm EST (Americas and Europe)

and 

 

Tuesday, August 11, 6:30pm EST (Asia and Australia/NZ)

We have an outstanding lineup of trainees who will present at the DataBlitz.

 

We had 31 submissions (!!) that will be presented in three sessions.

The first two sessions will be held in parallel on August 6 at 3pm EST and the third session will be held on August 11 at 6:30pm EST. All presenters have been contacted and assigned their timeslots. All trainees will get feedback on their presentations. 

An overview of the DataBlitz, including instructions, judges panel, and timings is available here.

The Abstracts and Order of Presentations for each of the DataBlitz events can be found here:

DataBlitz 1 - Room 1

DataBlitz 1 - Room 2

DataBlitz 2

Prizes will be announced on August 15, 2020.

Prizes sponsored by:

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Thursday, July 16, 4 pm EST 

Title: “But for pain words are lacking”: using language features to predict placebo analgesia in chronic pain. (New Data; Unpublished work)

Presented by: Dr. Paulo Branco, Postdoctoral Fellow at Apkarian Pain and Passions lab, Northwestern University, Chicago, USA.

Abstract: “But for pain words are lacking”, writes Virginia Woolf in her Magnum Opus, The Waves. And indeed, even though language is rich in meaning and is seen as “a window to the soul”, the discourse of patients with chronic illness and pain – like Woolf herself – have long been neglected. Natural language processing (NLP) is a relatively popular technique that extracts languages features out of discourse reflecting the person’s personality, behavior and mood. In this study, we hypothesize that chronic back pain patients who respond to placebo will show specific language patterns that can be picked up, quantified, and used to classify and infer the extent of analgesia after placebo pill ingestion. We were able to classify placebo responders with high accuracy (79% cross-validated). Further, with just three language features (semantic proximity to stigma, identity, and text tags associated with achievement) we were able to explain 50% of the variance in the reported pain after treatment. Predictive language features were also associated with personality traits and are not explained by treatment effects alone. Together, these show high promise to the use of quantitative language features to study placebo analgesia and have important implications for both the design of clinical trials and, conceivably, for identifying subjects that can benefit from placebo as a treatment option for chronic pain.

Thursday, July 9, 3 pm EST 

PANEL DISCUSSION: WHAT HAS ​IMAGING ADDED TO OUR UNDERSTANDING OF PAIN

A recent editorial in the journal Brain (https://academic.oup.com/brain/article-abstract/143/4/1045/5823483?redirectedFrom=fulltextcriticized brain imaging (in particular fMRI) and stated that it has offered little to our understanding of brain-based disease, and has little (if any) clinical utility. 

I thought it would be a good exercise to have a discussion about fMRI/sMRI papers that have had a meaningful impact on our mechanistic understanding of pain, or that have had meaningful clinical impact. This is a useful exercise for us to pull back and to think about the work we do.

 

Several faculty members have offered to participate, including:

David A. Seminowicz, Associate Professor, University of Maryland School of Dentistry, USA

Flavia Mancini, MRC Career Development Fellow, Cambridge University, UK 

Markus Ploner, Heisenberg Professor of Human Pain Research, TUM, Germany

Irene Tracey, Nuffield Chair in Anesthetic Science, Oxford University, UK

Marco Loggia, Associate Professor of Radiology, Harvard Medical School, USA

Ulrike Bingel, Professor in Clinical Neuroscience, University Hospital Essen, Germany

Tor Wager, Diana L. Taylor Distinguished Professor, Dartmouth, USA

Javeria Hashmi, Canada Research Chair (CRC) Tier II (Pain), Dalhousie University, Canada

Marina Lopez-SolaSerra Hunter Lecturer Prof, University of Barcelona, Spain

POSTPONED

DETAILS TO FOLLOW

Thursday, July 2, 3 pm EST 

SYMPOSIUM: ​PAIN AND EMOTION—BRAIN, BODY, AND BEYOND

Pain and emotion are tightly linked, but are traditionally studied and treated separately. This symposium highlights conceptual, psychological, and neural intersections between these two constructs, emphasizing opportunity for collaborations across the pain and affective science research and clinical communities. Our diverse panel of speakers combine innovative experimental methodologies and conceptual models, from basic animal and human research, to clinical research in chronic pain patients

Presenter information:

Gadi Gilam, gadig@stanford.edu

Gregory Corder, gregory.corder@pennmedicine.upenn.edu

Siri Leknes, siri.leknes@psykologi.uio.no

Rachel Aaron, raaron4@jhmi.edu

Thursday, June 18, 4 pm EST 

Geuter et al. Multiple Brain Networks Mediating Stimulus-Pain Relationships in Humans. Cerebral Cortex 30(7): 4204–4219
https://doi.org/10.1093/cercor/bhaa048

Presented by: Prof. Tor Wager, Diana L. Taylor Distinguished Professor, Dartmouth, USA

 

Wager_COVID19_JC

Thursday, June 4, 3 pm EST 

Guo et al. Ultralow-frequency neural entrainment to pain. PLoS Biology. 18(4): e3000491. https://doi.org/10.1371/journal.pbio.3000491

Presented by: Dr. Yifei Guo and Dr. Rory Bufacchi, Postdoctoral Fellow, Iannetti Lab, Italian Institute of Technology, Rome, Italy

 

Thursday, May 21, 4 pm EST 

Title: "Mindfulness engages a novel pain modulatory neural pathway" - Preprint Talk

Presented by: Dr. Fadel Zeidan, Assistant Professor, Department of Anesthesiology, UCSD, USA

(This is new work from Fadel's lab)

Thursday, May 7, 3 pm EST 

Makari et al. Loss of nucleus accumbens low-frequency fluctuations is a signature of chronic pain. Proceedings of the National Academy of Sciences, in press. DOI: 10.1073/pnas.1918682117

Paper: https://www.pnas.org/content/early/2020/04/15/1918682117.short?rss=1

Presented by: Dr. Paul Geha, Assistant Professor, University of Rochester, USA

Thursday, April 30, 3 pm EST 

Lim et al. Threat Prediction from Schemas as a Source of Bias in Pain Perception. Journal of Neuroscience 40 (7): 1538-1548, 2020. 

 

Paper: https://www.jneurosci.org/content/40/7/1538

Presented by: Dr. Javeria Hashmi, Canada Research Chair (CRC) Tier II (Pain), Department of Anesthesia, Pain Management & Perioperative Medicine, Dalhousie University, Canada

Thursday, April 2, 4 pm EST 

Lettieri et al. Emotionotopy in the human right temporo-parietal cortex. Nature Communications 10: 5568 (2019).

Paper: https://www.nature.com/articles/s41467-019-13599-z

Presented by: Massieh Moayedi, Assistant Professor and Co-Director of the Centre for Sensorimotor and Pain Research, University of Toronto, Canada

Thursday, April 16, 4 pm EST 

Furman et al. Sensorimotor peak alpha frequency is a reliable biomarker of pain sensitivity. BiorXiv (preprint).

Paper: https://academic.oup.com/cercor/article/30/12/6069/5863434?guestAccessKey=b9482629-ed20-4e55-88a1-3f3257aab3d7 

Presented by: Andrew Furman, PhD Candidate, Seminowicz Lab, University of Maryland, USA

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