Human Pain Seminar Series
This series was borne out of the COVID-19 Global Pandemic, which posed significant challenges to the pain community. Its purpose was to reinforce the message that the we—those who do human pain research—are part of a community.
I put together the #WeAreAllInThisTogether COVID-19 Journal Club. It's an opportunity to connect, to remain intellectually stimulated, to learn, and to keep up with the literature.
It has evolved into a Seminar Series that highlights the work of our community, and allows members of the community at any stage of their career engage with the speakers.
We are supported by the University of Toronto Centre for the Study of Pain.
We meet over Zoom every so often - about every 3 weeks. The specifics, papers, and link to the Zoom will be posted here.
We look forward to seeing you all.
If you wish to be added to the listserv to receive regular updates, please email Massieh.
Tuesday, February 27 2024 @ 11:00am EST
Title: Neural Reorganization: Fact or Faction?
Presented by: Dr. Hunter R. Schone, Postdoctoral Researcher, University of Pittsburgh, Pennsylvania, United States
Neuroscientists have long debated the adult brain’s capacity to reorganize itself in response to injury. A driving model for studying plasticity has been limb amputation. For decades, it was believed that amputation triggers large-scale reorganization of cortical body resources. However, these studies have relied on cross-sectional observations post-amputation, without directly tracking neural changes. Here, we longitudinally followed adult patients with planned arm amputations and measured hand and face representations, before and after amputation. By interrogating the representational structure elicited from movements of the hand (pre-amputation) and phantom hand (post-amputation), we demonstrate that hand representation is unaltered. Further, we observed no evidence for lower face (lip) reorganization into the deprived hand region. Collectively, our findings provide direct and decisive evidence that amputation does not trigger large-scale cortical reorganization. Contextualized with the complete ineffectiveness of phantom limb pain treatments in the field designed to reverse supposed maladaptive reorganization, I will make the case against cortical reorganization and its role in phantom limb pain.
Meeting ID: 852 2783 7808
Relevant Paper: https://www.biorxiv.org/content/10.1101/2023.12.13.571314v1.full
Wednesday, March 6 2024 @ 11:00am EST