#WeAreAllInThis Together COVID-19 Journal Club
The COVID-19 Global Pandemic has posed significant challenges to the pain community. To reinforce the message that the we—those who do human pain research—are part of a community, I put together the COVID-19 Journal Club (or as some like to call it, the #PainStars Forum). It's an opportunity to connect, to remain intellectually stimulated, to learn, and to keep up with the literature.
We meet over Zoom every month, on a Thursday. The specifics, papers, and link to the Zoom will be posted here. We look forward to seeing you all. And #WeAreAllInThisTogether.
If you would like to receive regular updates and Reminders about the Journal Club, please subscribe here: https://forms.gle/L44ap8VBjHRNdeE7A
Wednesday, September 23, 3pm EST
Title: Using fMRI hyperscanning to investigate the patient-clinician relationship in chronic pain: The role of therapeutic alliance, behavioral mirroring, and brain-to-brain concordance in therapeutic pain relief
Presented by: Dr. Dan-Mikael Ellingsen, Postdoctoral research fellow (Napadow Lab), Harvard Medical School and Martinos Center for Biomedical imaging, Boston, USA.
Abstract: The patient-clinician interaction can powerfully shape treatment outcomes such as pain, but is often considered an intangible “art-of-medicine”, and has largely eluded scientific inquiry. Although brain correlates of social processes such as em- pathy and theory-of-mind have been studied using single-subject designs, the spe- cific behavioral and neural mechanisms underpinning the patient-clinician interac- tion are unknown. Using a two-person interactive design, we simultaneously rec- orded functional MRI (i.e. hyperscanning) in patient-clinician dyads, who interacted via live video while clinicians treated evoked pain in chronic pain patients. Our re- sults show that patient analgesia is mediated by patient-clinician nonverbal behav- ioral mirroring and brain-to-brain concordance in circuitry implicated in theory-of- mind and social mirroring. Dyad-based analyses showed extensive dynamic cou- pling of these brain nodes with the partners’ brain activity, yet only in dyads where clinical rapport had been established prior to the interaction. These findings point to a putatively key brain-behavioral mechanism for therapeutic alliance and psycho- social analgesia.
Relevant Paper: Ellingsen et al. Dynamic brain-to-brain concordance and behavioral mirroring as a mechanism of the patient-clinician interaction. bioRxiv 2020.08.05.237511
Meeting ID: 875 6223 3925
Thursday, October 22, 3pm EST
Title: The Distributed Nociceptive System: A Framework for Understanding Pain
Presented by: Dr. Robert C. Coghill, Director, Center for Understanding Pediatric Pain (CUPP), Professor of Pediatrics Behavioral Medicine and Clinical Psychology, Cincinnati Children’s Hospital Medical Center
Abstract: Chronic pain remains challenging to both diagnose and treat. These challenges, in part, arise from limited systems-level understanding of the basic mechanisms that process nociceptive information and ultimately instantiate a subjectively available experience of pain. Here, I provide a framework, the distributed nociceptive system, for understanding nociceptive mechanisms at a systems level by integrat- ing the concepts of neural population coding with distributed processing. Within this framework, wide-spread engagement of populations of neurons produces representations of nociceptive information that are highly resilient to disruption. The distributed nociceptive system provides a foundation for understanding complex spatial aspects of chronic pain and provides an impetus for nonpharmacological cognitive and physical therapies that can effectively target the highly distributed system that gives rise to an experience of pain.
Relevant Paper: https://doi.org/10.1016/j.tins.2020.07.004
Meeting ID: 815 8409 3128
Past Journal Clubs
I would like to start by thanking all the trainees for presenting their data at our DataBlitz. The presentations were of very high quality. It was a really successful event, and it achieved — at least for me — to build a sense of community.
We had 29 presentations representing 25 labs.
I would also like to thank the judges, Lauren Atlas, Rachael Bosma, Iacopo Cioffi, Yenisel Cruz-Almeida, Patrick Finan, and Laura Stone, for their time and thoughtful comments. None of this would have been possible without them.
I would also like to thank the sponsors: IASP, the Canadian Pain Society and QST-Lab.
1st place: Ishtiaq Mawla
University of Michigan, USA
PI: Richard Harris and Vitaly Napadow
Title: Greater Somatosensory Afference with Acupuncture Increases Primary Somatosensory Connectivity and alleviates Fibromyalgia Pain via Insular GABA
2nd place: Samantha Millard
University of Birmingham, UK
PI: Ali Mazaheri
Title: Predicting Post-operative Pain in Lung Cancer Patients using Pre-operative Peak Alpha Frequency
3rd place: Lewis Crawford
University of Sydney, Australia
PI: Luke Henderson
Title: Brainstem mechanisms of placebo and nocebo pain modulation
1. Joana Barroso, Northwestern University, USA. PI: Vania Apkarian
“Disruption of Brain’s Functional Hub Topology in Chronic Osteoarthritis Pain”
2. Claire Lunde, Boston Children’s Hospital, USA. PI: Eric Moulton
“Long-term impact of cerebellar mass resection on pain processing, and cognitive and emotional sequelae: mixed methodology"
Prizes sponsored by:
Thursday, August 6, 3pm EST (Americas and Europe)
Tuesday, August 11, 6:30pm EST (Asia and Australia/NZ)
We have an outstanding lineup of trainees who will present at the DataBlitz.
We had 31 submissions (!!) that will be presented in three sessions.
The first two sessions will be held in parallel on August 6 at 3pm EST and the third session will be held on August 11 at 6:30pm EST. All presenters have been contacted and assigned their timeslots. All trainees will get feedback on their presentations.
An overview of the DataBlitz, including instructions, judges panel, and timings is available here.
The Abstracts and Order of Presentations for each of the DataBlitz events can be found here:
Prizes will be announced on August 15, 2020.
Prizes sponsored by:
Thursday, July 16, 4 pm EST
Title: “But for pain words are lacking”: using language features to predict placebo analgesia in chronic pain. (New Data; Unpublished work)
Presented by: Dr. Paulo Branco, Postdoctoral Fellow at Apkarian Pain and Passions lab, Northwestern University, Chicago, USA.
Abstract: “But for pain words are lacking”, writes Virginia Woolf in her Magnum Opus, The Waves. And indeed, even though language is rich in meaning and is seen as “a window to the soul”, the discourse of patients with chronic illness and pain – like Woolf herself – have long been neglected. Natural language processing (NLP) is a relatively popular technique that extracts languages features out of discourse reflecting the person’s personality, behavior and mood. In this study, we hypothesize that chronic back pain patients who respond to placebo will show specific language patterns that can be picked up, quantified, and used to classify and infer the extent of analgesia after placebo pill ingestion. We were able to classify placebo responders with high accuracy (79% cross-validated). Further, with just three language features (semantic proximity to stigma, identity, and text tags associated with achievement) we were able to explain 50% of the variance in the reported pain after treatment. Predictive language features were also associated with personality traits and are not explained by treatment effects alone. Together, these show high promise to the use of quantitative language features to study placebo analgesia and have important implications for both the design of clinical trials and, conceivably, for identifying subjects that can benefit from placebo as a treatment option for chronic pain.
Thursday, July 9, 3 pm EST
PANEL DISCUSSION: WHAT HAS IMAGING ADDED TO OUR UNDERSTANDING OF PAIN
A recent editorial in the journal Brain (https://academic.oup.com/brain/article-abstract/143/4/1045/5823483?redirectedFrom=fulltext) criticized brain imaging (in particular fMRI) and stated that it has offered little to our understanding of brain-based disease, and has little (if any) clinical utility.
I thought it would be a good exercise to have a discussion about fMRI/sMRI papers that have had a meaningful impact on our mechanistic understanding of pain, or that have had meaningful clinical impact. This is a useful exercise for us to pull back and to think about the work we do.
Several faculty members have offered to participate, including:
David A. Seminowicz, Associate Professor, University of Maryland School of Dentistry, USA
Flavia Mancini, MRC Career Development Fellow, Cambridge University, UK
Markus Ploner, Heisenberg Professor of Human Pain Research, TUM, Germany
Irene Tracey, Nuffield Chair in Anesthetic Science, Oxford University, UK
Marco Loggia, Associate Professor of Radiology, Harvard Medical School, USA
Ulrike Bingel, Professor in Clinical Neuroscience, University Hospital Essen, Germany
Tor Wager, Diana L. Taylor Distinguished Professor, Dartmouth, USA
Javeria Hashmi, Canada Research Chair (CRC) Tier II (Pain), Dalhousie University, Canada
Marina Lopez-Sola, Serra Hunter Lecturer Prof, University of Barcelona, Spain
DETAILS TO FOLLOW
Thursday, July 2, 3 pm EST
SYMPOSIUM: PAIN AND EMOTION—BRAIN, BODY, AND BEYOND
Pain and emotion are tightly linked, but are traditionally studied and treated separately. This symposium highlights conceptual, psychological, and neural intersections between these two constructs, emphasizing opportunity for collaborations across the pain and affective science research and clinical communities. Our diverse panel of speakers combine innovative experimental methodologies and conceptual models, from basic animal and human research, to clinical research in chronic pain patients
Gadi Gilam, email@example.com
Gregory Corder, firstname.lastname@example.org
Siri Leknes, email@example.com
Rachel Aaron, firstname.lastname@example.org
Thursday, June 18, 4 pm EST
Geuter et al. Multiple Brain Networks Mediating Stimulus-Pain Relationships in Humans. Cerebral Cortex 30(7): 4204–4219
Presented by: Prof. Tor Wager, Diana L. Taylor Distinguished Professor, Dartmouth, USA
Thursday, June 4, 3 pm EST
Guo et al. Ultralow-frequency neural entrainment to pain. PLoS Biology. 18(4): e3000491.
Presented by: Dr. Yifei Guo and Dr. Rory Bufacchi, Postdoctoral Fellow, Iannetti Lab, Italian Institute of Technology, Rome, Italy
Thursday, May 21, 4 pm EST
Title: "Mindfulness engages a novel pain modulatory neural pathway" - Preprint Talk
Presented by: Dr. Fadel Zeidan, Assistant Professor, Department of Anesthesiology, UCSD, USA
(This is new work from Fadel's lab)
Thursday, May 7, 3 pm EST
Makari et al. Loss of nucleus accumbens low-frequency fluctuations is a signature of chronic pain. Proceedings of the National Academy of Sciences, in press. DOI: 10.1073/pnas.1918682117
Presented by: Dr. Paul Geha, Assistant Professor, University of Rochester, USA
Thursday, April 30, 3 pm EST
Lim et al. Threat Prediction from Schemas as a Source of Bias in Pain Perception. Journal of Neuroscience 40 (7): 1538-1548, 2020.
Presented by: Dr. Javeria Hashmi, Canada Research Chair (CRC) Tier II (Pain), Department of Anesthesia, Pain Management & Perioperative Medicine, Dalhousie University, Canada
Thursday, April 2, 4 pm EST
Lettieri et al. Emotionotopy in the human right temporo-parietal cortex. Nature Communications 10: 5568 (2019).
Presented by: Massieh Moayedi, Assistant Professor and Co-Director of the Centre for Sensorimotor and Pain Research, University of Toronto, Canada
Thursday, April 16, 4 pm EST
Furman et al. Sensorimotor peak alpha frequency is a reliable biomarker of pain sensitivity. BiorXiv (preprint).
Presented by: Andrew Furman, PhD Candidate, Seminowicz Lab, University of Maryland, USA